Oh Lab

In the post-genomic era, the significance of noncoding RNAs has reshaped our comprehension significantly. Despite 80-90% of the human genome undergoing transcription, merely about 2% of it encodes proteins. Among the transcripts, a substantial portion comprises long noncoding RNAs (lncRNAs), yet a majority of these lncRNAs still lack thorough functional exploration.

Our research focuses on deciphering how lncRNAs orchestrate the complex process of gene expression, particularly in controlling the 3D epigenome throughout developmental stages, homeostasis, and various diseases. Our findings lay a foundation for RNA-based therapeutic avenues.